JPH0134204B2 - - Google Patents
Info
- Publication number
- JPH0134204B2 JPH0134204B2 JP56501036A JP50103681A JPH0134204B2 JP H0134204 B2 JPH0134204 B2 JP H0134204B2 JP 56501036 A JP56501036 A JP 56501036A JP 50103681 A JP50103681 A JP 50103681A JP H0134204 B2 JPH0134204 B2 JP H0134204B2
- Authority
- JP
- Japan
- Prior art keywords
- heme
- ethanol
- mixture
- volume
- paste
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 331
- 150000003278 haem Chemical class 0.000 claims description 158
- 239000000203 mixture Substances 0.000 claims description 83
- 239000012141 concentrate Substances 0.000 claims description 53
- 210000004369 blood Anatomy 0.000 claims description 25
- 239000008280 blood Substances 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 21
- 239000000126 substance Substances 0.000 claims description 21
- 102000001554 Hemoglobins Human genes 0.000 claims description 18
- 108010054147 Hemoglobins Proteins 0.000 claims description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- 102000018146 globin Human genes 0.000 claims description 11
- 108060003196 globin Proteins 0.000 claims description 11
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 5
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000012024 dehydrating agents Substances 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229940095064 tartrate Drugs 0.000 claims description 2
- 208000005156 Dehydration Diseases 0.000 claims 5
- 230000018044 dehydration Effects 0.000 claims 5
- 238000006297 dehydration reaction Methods 0.000 claims 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 235000019270 ammonium chloride Nutrition 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 230000006920 protein precipitation Effects 0.000 claims 1
- 235000015424 sodium Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 229910021653 sulphate ion Inorganic materials 0.000 claims 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 81
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 57
- 239000002994 raw material Substances 0.000 description 44
- 239000006228 supernatant Substances 0.000 description 38
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 35
- 102000004169 proteins and genes Human genes 0.000 description 27
- 108090000623 proteins and genes Proteins 0.000 description 27
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 24
- 210000003743 erythrocyte Anatomy 0.000 description 24
- 229910052742 iron Inorganic materials 0.000 description 17
- 239000000243 solution Substances 0.000 description 13
- 239000004471 Glycine Substances 0.000 description 12
- 238000001816 cooling Methods 0.000 description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
- 239000000284 extract Substances 0.000 description 11
- 238000000605 extraction Methods 0.000 description 10
- 239000002244 precipitate Substances 0.000 description 10
- 238000003756 stirring Methods 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 8
- 239000005457 ice water Substances 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 238000001556 precipitation Methods 0.000 description 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 5
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 5
- 235000011130 ammonium sulphate Nutrition 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- -1 iron Heme Chemical class 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 238000004925 denaturation Methods 0.000 description 3
- 230000036425 denaturation Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- ZJDIMSMQXMWMCF-UHFFFAOYSA-N Dimethylhistamine Natural products CN(C)CCC1=CN=CN1 ZJDIMSMQXMWMCF-UHFFFAOYSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 229940025294 hemin Drugs 0.000 description 2
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 description 2
- 229940082629 iron antianemic preparations Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 description 1
- VIXMOEKUHKZJMV-UHFFFAOYSA-N 2-(1h-imidazol-2-ylamino)acetic acid Chemical compound OC(=O)CNC1=NC=CN1 VIXMOEKUHKZJMV-UHFFFAOYSA-N 0.000 description 1
- YJLUBHOZZTYQIP-UHFFFAOYSA-N 2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NN=C(O1)CC(=O)N1CC2=C(CC1)NN=N2 YJLUBHOZZTYQIP-UHFFFAOYSA-N 0.000 description 1
- QSJLIYHZRBDCLB-UHFFFAOYSA-N 2-hydroxy-2-(1h-imidazol-2-yl)propanoic acid Chemical compound OC(=O)C(O)(C)C1=NC=CN1 QSJLIYHZRBDCLB-UHFFFAOYSA-N 0.000 description 1
- 108010085443 Anserine Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 description 1
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- 108010087806 Carnosine Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- WRYCSMQKUKOKBP-UHFFFAOYSA-N Imidazolidine Chemical compound C1CNCN1 WRYCSMQKUKOKBP-UHFFFAOYSA-N 0.000 description 1
- VSFNAZLYGOOSEY-UHFFFAOYSA-N Imidazolylpropionic acid Natural products OC(=O)CCN1C=CN=C1 VSFNAZLYGOOSEY-UHFFFAOYSA-N 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical class OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- SLRNWACWRVGMKD-UHFFFAOYSA-N L-anserine Natural products CN1C=NC(CC(NC(=O)CCN)C(O)=O)=C1 SLRNWACWRVGMKD-UHFFFAOYSA-N 0.000 description 1
- SSISHJJTAXXQAX-ZETCQYMHSA-N L-ergothioneine Chemical compound C[N+](C)(C)[C@H](C([O-])=O)CC1=CNC(=S)N1 SSISHJJTAXXQAX-ZETCQYMHSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 241000210053 Potentilla elegans Species 0.000 description 1
- QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- GPPYTCRVKHULJH-UHFFFAOYSA-O [1-carboxy-2-(1h-imidazol-5-yl)ethyl]-trimethylazanium Chemical compound C[N+](C)(C)C(C(O)=O)CC1=CN=CN1 GPPYTCRVKHULJH-UHFFFAOYSA-O 0.000 description 1
- JQRLYSGCPHSLJI-UHFFFAOYSA-N [Fe].N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 Chemical class [Fe].N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 JQRLYSGCPHSLJI-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- MYYIAHXIVFADCU-QMMMGPOBSA-N anserine Chemical compound CN1C=NC=C1C[C@H](NC(=O)CC[NH3+])C([O-])=O MYYIAHXIVFADCU-QMMMGPOBSA-N 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 1
- 229940044199 carnosine Drugs 0.000 description 1
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- ZCKYOWGFRHAZIQ-UHFFFAOYSA-N dihydrourocanic acid Chemical compound OC(=O)CCC1=CNC=N1 ZCKYOWGFRHAZIQ-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940093497 ergothioneine Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011790 ferrous sulphate Substances 0.000 description 1
- 235000003891 ferrous sulphate Nutrition 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 235000000396 iron Nutrition 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 125000001095 phosphatidyl group Chemical group 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 229960001416 pilocarpine Drugs 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108020001775 protein parts Proteins 0.000 description 1
- 229950003776 protoporphyrin Drugs 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960003732 tyramine Drugs 0.000 description 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/06—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/017—Hydrolysed proteins; Derivatives thereof from animals from blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8002591A SE440596B (sv) | 1980-04-03 | 1980-04-03 | Forfarande for framstellning av ett heme-koncentrat ur en blandning av heme och blodsubstans erhallen vid spaltning av hemoglobin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57500431A JPS57500431A (en]) | 1982-03-11 |
| JPH0134204B2 true JPH0134204B2 (en]) | 1989-07-18 |
Family
ID=20340685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56501036A Expired JPH0134204B2 (en]) | 1980-04-03 | 1981-04-01 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4431581A (en]) |
| EP (1) | EP0056025B1 (en]) |
| JP (1) | JPH0134204B2 (en]) |
| DK (1) | DK154266C (en]) |
| IE (1) | IE51040B1 (en]) |
| IN (1) | IN152639B (en]) |
| SE (1) | SE440596B (en]) |
| SU (1) | SU1660573A3 (en]) |
| WO (1) | WO1981002834A1 (en]) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2548671B1 (fr) * | 1983-07-07 | 1986-05-02 | Merieux Inst | Procede de preparation de globine a partir d'hemoglobine et globine obtenue par ce procede |
| FI68970C (fi) * | 1983-08-10 | 1985-12-10 | Medica Pharma Co Ltd | Foerfarande foer framstaellning av en ny medicinskt anvaendbarhemin-foerening |
| US4914084A (en) * | 1984-05-09 | 1990-04-03 | Synthetic Blood Corporation | Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body |
| FR2714380B1 (fr) * | 1993-12-24 | 1996-05-24 | Bioxytech | Utilisation de dérivés 2-mercapto-imidazole substitués en position 4 (ou 5) comme agents antioxydants, leur procédé de préparation et leurs applications en pharmacie, cosmétique ou alimentaire. |
| DK0946563T3 (da) * | 1996-12-20 | 2002-11-04 | Fraunhofer Ges Forschung | Fremgangsmåde til udvinding af hæmatitjern fra slagteblod |
| US6845820B1 (en) * | 2000-10-19 | 2005-01-25 | Weatherford/Lamb, Inc. | Completion apparatus and methods for use in hydrocarbon wells |
| US6749872B2 (en) * | 2002-02-01 | 2004-06-15 | The Lauridsen Group Incorporated | Heme supplement and method of using same |
| CN102599332B (zh) * | 2012-03-09 | 2014-07-30 | 上海杰隆生物制品股份有限公司 | 一种利用禽血生产低灰分禽血浆蛋白粉的方法 |
| CN103536670A (zh) * | 2013-10-17 | 2014-01-29 | 新疆天海绿洲农业科技股份有限公司 | 一种改善营养性贫血的组合物及其制备方法 |
| CN103610828B (zh) * | 2013-12-10 | 2015-10-28 | 王怀兰 | 治疗女性贫血中药组合物及制备方法 |
| KR20180079846A (ko) | 2017-01-03 | 2018-07-11 | 주식회사 인트론바이오테크놀로지 | 돼지 피로부터 유래되지 않은 헴철을 제조할 수 있는 생물학적 방법 |
| KR101894575B1 (ko) | 2017-01-03 | 2018-09-04 | 주식회사 인트론바이오테크놀로지 | 돼지 피로부터 유래되지 않은 헴철을 제조할 수 있는 화학적 방법 |
| US20250109161A1 (en) * | 2021-11-30 | 2025-04-03 | National University Of Singapore | Heme, compositions and method of synthesis thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7715575A (en) * | 1974-01-08 | 1976-07-08 | Commw Scient Ind Res Org | Separation of protein from blood |
| AU492555B1 (en) * | 1974-01-08 | 1976-07-08 | Commonwealth Scientific And Industrial Research Organization | Separation of protein from blood |
| SE389596B (sv) * | 1974-06-14 | 1976-11-15 | P G S Lindroos | Saett att ur en vaetska innehallande blodsubstanser separera jaernfoereningar fran globin |
| SE7513987L (sv) * | 1975-12-11 | 1977-06-12 | Paul Goran Sigvard Lindroos | Sett att behandla vetskor innehallande blodsubstanser |
| US4098780A (en) * | 1975-06-04 | 1978-07-04 | Paul Goran Sigvard Lindroos | Method of treating liquids containing blood substances |
| CA1126653A (en) * | 1978-12-22 | 1982-06-29 | Jan H. Luijerink | Process of preparing blood cell protein and heme from hemoglobin |
-
1980
- 1980-04-03 SE SE8002591A patent/SE440596B/sv not_active IP Right Cessation
-
1981
- 1981-03-24 IE IE644/81A patent/IE51040B1/en unknown
- 1981-04-01 JP JP56501036A patent/JPH0134204B2/ja not_active Expired
- 1981-04-01 US US06/324,395 patent/US4431581A/en not_active Expired - Fee Related
- 1981-04-01 WO PCT/FI1981/000026 patent/WO1981002834A1/en active IP Right Grant
- 1981-04-01 EP EP81900824A patent/EP0056025B1/en not_active Expired
- 1981-04-02 IN IN371/CAL/81A patent/IN152639B/en unknown
- 1981-11-30 DK DK530181A patent/DK154266C/da not_active IP Right Cessation
- 1981-11-30 SU SU813359217A patent/SU1660573A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| SU1660573A3 (ru) | 1991-06-30 |
| WO1981002834A1 (en) | 1981-10-15 |
| IE51040B1 (en) | 1986-09-17 |
| IN152639B (en]) | 1984-02-25 |
| DK154266B (da) | 1988-10-31 |
| DK530181A (da) | 1981-11-30 |
| IE810644L (en) | 1981-10-03 |
| EP0056025A1 (en) | 1982-07-21 |
| SE8002591L (sv) | 1981-10-04 |
| JPS57500431A (en]) | 1982-03-11 |
| DK154266C (da) | 1989-03-28 |
| SE440596B (sv) | 1985-08-12 |
| US4431581A (en) | 1984-02-14 |
| EP0056025B1 (en) | 1985-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0134204B2 (en]) | ||
| Lyman et al. | Reactions of proteins with gossypol | |
| US8946202B2 (en) | Substituted porphyrins | |
| US20120071552A1 (en) | Zinc-Monocysteine Complex and Method Of Using Zinc-Cysteine Complexes | |
| NL8602248A (nl) | Werkwijze voor het bereiden van een sojaproteine-isolaat met laag fytaatgehalte. | |
| Lemberg et al. | Coupled oxidation of ascorbic acid and haemoglobin: Studies on the formation of bile pigments from choleglobin and verdohaemochromogen and on their isolation from erythrocytes | |
| CN110191891B (zh) | 用于制备不是源自猪血的血红素铁的化学方法 | |
| JPS5963139A (ja) | ひまわりの種子から得られる蛋白分離物およびその製造方法 | |
| US3895106A (en) | Novel CSA and CSC for use in man and mammals to inhibit atherosclerosis and the recurrence of cardiovascular incidents in atherosclerotic mammals | |
| CN116138442A (zh) | 一种罗勒多糖-多酚-蛋白质复合物的制备方法及其应用 | |
| CN112898410B (zh) | 一种中国鲎血蓝蛋白及其制备方法和应用 | |
| US2488564A (en) | Preparation of hyaluronidase | |
| US4464296A (en) | Solubilization of dry protein in aqueous or acidic media after treatment with concentrated hydrogen peroxide | |
| EP0444199B1 (en) | Ascorbic acid derivatives | |
| Surgenor et al. | Preparation and properties of serum and plasma proteins, XXXV: A system of protein fractionation using zinc complexes | |
| IE49166B1 (en) | Process for separating off iron compounds originating from haemoglobin from globin in a liquid containing blood substances | |
| JP3226359B2 (ja) | 過酸化脂質生成抑制剤及びこれを含有する組成物 | |
| JPS62209100A (ja) | 生体に有用な性質を持つグロビン及びアセチルグロビンの鉄誘導体、その調製法及び薬学的処方物 | |
| KR102305089B1 (ko) | 멍게체액 추출물의 제조방법 | |
| US3660237A (en) | Process for obtaining kallekrein from pancreas or submandibularis glands of pigs | |
| US2770570A (en) | Method of obtaining intrinsic factor preparations of enhanced potency | |
| US6217932B1 (en) | Method of obtaining haemin from slaughter blood | |
| KR100245571B1 (ko) | 메일라드반응 억제개선제 | |
| JP3308497B2 (ja) | コーヒー豆から抽出されたｓｏｄ様抽出組成物 | |
| JP2002119218A (ja) | 低イソフラボン大豆蛋白及びその製造法 |